The Diagnostic Challenge
Diagnosing Alzheimer's Dementia is a 3-part Challenge
There is not one confirming test for Alzheimer's and early symptoms mimic other conditions.
Accurate diagnosis requires deep evaluation by specialists.
PCPs don't have easy tools to determine who should be sent to a Alzheimer's specialist.
What is needed is a quick and affordable test Primary Care Physicians can deploy to determine of the patient's memory symptoms require further evaluation by a specialist.
COMING in 2026
NeuroFirst™ Memory, a simple blood test that can determine that a person with possible early symptoms does not have Alzheimer’s Dementia, granting them and their family peace of mind, and sparing them costly and invasive forms of testing.
NeuroFirst™ Memory tests combine proteomics biomarkers with AI machine learning algorithms to “Rule Out” Alzheimer’s Dementia. We measure a large number of proteins in blood along with sophisticated algorithms, trained on thousands of clinical samples, to drive the results of our tests.
Additional tests are under development for Parkinson’s Disease, Frontal Temporal Dementia and Lewy Body Syndrome. See our pipeline for more details.
Not all memory problems are caused by Alzheimer’s Dementia.
NeuroFirst Memory helps to rule out Alzheimer’s Dementia and some other dementias.
Properly diagnosing the causes of memory issues can lead to earlier detection of Alzheimer’s Dementia — when both drug therapies and lifestyle changes can help prolong cognition.
Why amyloid/tau-based blood tests are not appropriate as the first triage test at the primary care level
- Too many patients who would benefit from a secondary consultation would be missed. 25% of patients with clinically diagnosed mild/moderate Alzheimer’s have no beta amyloid pathology, especially in diverse population. These patients may benefit from other available therapies.
- 33% of cognitively normal people ages 70+ have some amyloid pathology. These patients might be falsely “ruled in” and possibly diagnosed with Alzheimer’s, thereby increasing the number of patients being referred for unnecessary neurological evaluation and causing undue stress on the patient as well.